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STRUCTURE REFINEMENT OF 3-ARYL-COUMARINS SYNTHETIC MODEL WITH 1, 4-BENZODIOKSAN FRAGMENT BY MASS SPECTROMETRIC ANALYSIS

Ismailova G.O, Yuldashev N.M, Uzakbergenova Z.D, Kalimbetova R.Y, Atashov A.K
There is describe the characteristics of the possible ways of fragmentation of 3-(2,3-dihydro-benzo [1,4] dioxin-6-yl)-chromen-2-one synthetic model a mass spectrum. Mass spectrometric investigation of the synthesized new coumarin carried out on a Q-TOF LC-MS Agilent Technologies Series 6520V. It is shown that the fragmentation of 3-aryl-coumarin synthetic model with 1,4-benzodioksanovym fragment goes in four directions. Cleavage of coumarin in the first direction is the fragmentation of the molecular ion to form a secondary ion m/z 181, with the second m/z 152, the third fragment m/z 127 and the fourth direction is formed a fragment m/z 165. Synthesized new 3-aryl-coumarin with 1,4-benzodioksanovym fragment was investigated in vitro on M. antimycobacterial activity against Tuberculosis H37Rv in BACTEC-12B and Erdman, who took 49% of anti-TB activity.

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Исмаилова Г.О, Юлдашев Н.М, Узакбергенова З.Д, Калимбетова Р.Ю, Аташoв А.К УТОЧНЕНИЕ СТРУКТУРЫ СИНТЕТИЧЕСКОЙ МОДЕЛИ 3-АРИЛ-КУМАРИНА С 1,4-БЕНЗОДИОКСАНОВЫМ ФРАГМЕНТОМ С ПОМОЩЬЮ МАСС-СПЕКТРОМЕТРИЧЕСКОГО АНАЛИЗА // Научное обозрение. Химические науки. 2020. № 1. С. 15-15;
URL: https://science-chemistry.ru/en/article/view?id=12 (дата обращения: 28.07.2026).